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American Society of Microbiology ABMM Sample Questions (Q47-Q52):
NEW QUESTION # 47
During a primary infection with Epstein-Barr virus (EBV), the virus establishes latency in B lymphocytes.
The transition from lytic to latent infection is tightly regulated by viral gene expression. Which of the following viral proteins is crucial for the establishment and maintenance of EBV latency and is a key target in EBV-associated lymphomas?
- A. Viral capsid antigen (VCA)
- B. Glycoprotein gp350
- C. Early antigen (EA)
- D. Epstein-Barr nuclear antigen 1 (EBNA1)
Answer: D
NEW QUESTION # 48
A patient with a history of chronic lung disease develops a severe pneumonia. Bronchoalveolar lavage fluid reveals the presence of numerous cysts containing multiple nuclei, which stain positively with silver stains but poorly with Gram stain. The patient's CD4+ T-cell count is within the normal range. The MOST likely causative organism and the preferred treatment are:
- A. Histoplasma capsulatum; amphotericin B followed by itraconazole.
- B. Pneumocystis jirovecii; trimethoprim-sulfamethoxazole.
- C. Blastomyces dermatitidis; itraconazole.
- D. Paragonimus westermani; praziquantel.
Answer: B
NEW QUESTION # 49
A patient with a history of inflammatory bowel disease is diagnosed with primary sclerosing cholangitis and undergoes liver transplantation. Post-transplant, they develop a bloodstream infection with a Gram-negative bacterium that is identified as Fusobacterium nucleatum. This organism's role in the pathogenesis of colorectal cancer is primarily attributed to its ability to:
- A. Produce potent exotoxins that damage the intestinal epithelium.
- B. Directly induce mutations in colonic epithelial cells.
- C. Modulate the host immune response and promote a pro-inflammatory microenvironment.
- D. Form biofilms that physically obstruct the bile ducts.
Answer: C
NEW QUESTION # 50
A research team is investigating the mechanisms of antifungal resistance in Candida albicans. They identify a strain that exhibits resistance to azole antifungal agents. Further analysis reveals overexpression of a specific ATP-binding cassette (ABC) transporter protein in the resistant strain. This mechanism of resistance involves:
- A. Alteration of the fungal ergosterol biosynthesis pathway, the target of azoles.
- B. Increased degradation of the azole antifungal agent within the fungal cell.
- C. Active efflux of the azole antifungal agent out of the fungal cell.
- D. Modification of the fungal cell wall, preventing azole penetration.
Answer: C
NEW QUESTION # 51
A clinical microbiology laboratory is using isothermal nucleic acid amplification techniques for rapid detection of Mycobacterium tuberculosis in sputum. Compared to conventional PCR, isothermal methods offer the advantage of:
- A. Easier integration with downstream analysis techniques such as Sanger sequencing.
- B. Faster reaction times and the ability to be performed without sophisticated thermocyclers.
- C. The ability to simultaneously amplify multiple targets in a single reaction.
- D. Higher sensitivity and specificity for detecting low levels of target DNA.
Answer: B
NEW QUESTION # 52
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